Frequency of Hypomagnesaemia in patients presenting with Acute Coronary Syndrome
Keywords:
Hypomagnesaemia, acute coronary syndrome, STEMI, NSTEMI, unstable angina, serum magnesium levelAbstract
Background: Acute coronary syndrome (ACS) has been defined as a group of conditions due to decreased blood flow in the coronary arteries. Hypomagnesemia is an important risk factor cardiac patients. Although the frequency reported in previous literature is but controversy exits. So we conducted this study to find extent of problem in local population.
Aims and objective: To determine the frequency of hypomagnesaemia in patients presenting with acute coronary syndrome.
Material and methods: This cross sectional study was carried out at the department of Cardiology, Punjab Institute of Cardiology, Lahore over a period of six months from 05-09-2017 to 05-03-2018. Total 185 patients were enrolled in the study. Then blood sample was obtained and were sent to the laboratory of the hospital for assessment of magnesium level. Reports were assessed and if level is below normal, then hypomagnesemia was labeled.
Results: The mean age of patients was 59.48±13.35 years. There were 92 (49.7%) males and 93 (50.3%) females. The mean magnesium level of patients was 1.73±0.50mg/dl. In this study, 38 (20.5%) patients had hypomagnesemia while 147 (79.5%) had normal magnesium level.
Conclusion: The frequency of hypomagnesemia was low in our study but cannot be ignored.
Key words: Hypomagnesaemia, acute coronary syndrome, STEMI, NSTEMI, unstable angina, serum magnesium level
References
Nasim B, Sajjad A, Khan Z, Ali Z, Sheikh A, Yadgir T, et al. Prevalence of ACS and Causal Relation of Hypomagnesaemia.
Makoui RH. Evaluation of Serum Value of Magnesium in Patients with Acute Coronary Syndrome (ACS) and its Relationship with Occurrence of Arrhythmias. Middle-East Journal of Scientific Research 2012;12(8):1107-10.
Naroo G, Nasim B, Skaf O, Yadgir TA. Patient on ACS Pathway-Hypomagnesaemia a Contributory Factor to Myocardial Ischemia: INTECH Open Access Publisher; 2013: p. 133.
Reffelmann T, Ittermann T, Dörr M, Völzke H, Reinthaler M, Petersmann A, et al. Low serum magnesium concentrations predict cardiovascular and all-cause mortality. Atherosclerosis 2011;219(1):280-4.
Dasgupta A, Sarma D, Saikia UK. Hypomagnesemia in type 2 diabetes mellitus. Indian journal of endocrinology and metabolism 2012;16(6):1000.
Qin S-Y, Zhou Y, Jiang H-X, Hu B-L, Tao L, Xie M-z. The association of diabetes mellitus with clinical outcomes after coronary stenting: a meta-analysis. PloS one 2013;8(9):e72710.
Anjum MS, Iqbal S, Kalsoom N, Manzoor H. Frequency of hypomagnesaemia in patients with acute coronary syndrome. Professional Med J 2013;20(1):34-8.
Maciejewski P, Bednarz B, Chamiec T, Górecki A, ?ukaszewicz R, Ceremuzy?ski L. Acute coronary syndrome: potassium, magnesium and cardiac arrhythmia. Kardiologia polska 2003;59(11):402-7.
Mirmohammadi F, Derakhshanfar H, Kariman H, Tehrani MAM, Hatamabadi HR, Shahrami A, et al. Association between serum magnesium level and cardiac arrhythmias in patients with acute coronary syndrome. J Babol Univ Med Sci 2013;15(3):36-41.
Alzamani MI. The study of serum magnesium level in acute coronary syndrome patients. Malaysian J Med Sci 2006;13:28.
Chakraborti S, Chakraborti T, Mandal M, Mandal A, Das S, Ghosh S. Protective role of magnesium in cardiovascular diseases: a review. Molecular and cellular biochemistry 2002;238(1-2):163-79.
Ford ES. Serum magnesium and ischaemic heart disease: findings from a national sample of US adults. International journal of epidemiology 1999;28(4):645-51.
Hayes J, Ryan M, Brazil N, Riordan T, Walsh J, Coakley D. Serum hypomagnesaemia in an elderly day-hospital population. Irish medical journal 1989;82(3):117-9.
Arsenian MA. Magnesium and cardiovascular disease. Progress in cardiovascular diseases 1993;35(4):271-310.
Taneva E. Hypokaliaemia and hypomagnesemia during acute coronary syndrome: A?661. European Journal of Anaesthesiology (EJA) 2005;22:172.
Purvis JR, Movahed A. Magnesium disorders and cardiovascular diseases. Clinical cardiology 1992;15(8):556-68.
