Blood Loss and Allogeneic Transfusion Requirements in Normothermic CPB Relative to Hypothermic CPB
DOI:
https://doi.org/10.55958/jcvd.v20i1.167Keywords:
Blood Loss, Allogeneic Transfusion, Normothermic CPB, Hypothermic CPBAbstract
Objective: To determine the blood loss and allogeneic transfusion requirements in normothermic CPB relative to hypothermic CPB.
Material and Method: After obtaining institutional review board approval and informed patient consent, we conducted a prospective, randomized study of 130 patients undergoing CPB for a primary cardiac operation at normothermic (35°C) (n 57) or hypothermic temperature (25°C) (n 73). Blood loss and transfusion requirements in the operating room and for the ?rst 24 hours in the intensive care unit were determined. An independent t test was used. A p value of less than 0.05 was considered signi?cant.
Results: The present study shows that there is no difference between blood transfusion in both groups. Hypothermic patients bleed intraoperatively more than that of normothermic CPB patients.
Conclusion:
We found that when there was no difference in duration of CPB, normothermic and hypothermic CPB groups demonstrated similar blood transfusion requirements even though other studies have shown hypothermia induces platelet dysfunction and alters the activity of coagulation factors. But hypothermic patients bleed more during CPB than normothermic patients. Post-operative bleeding after 24 hours of CPB was same in both groups.
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