Comparison of Clinical Outcome of 20mg and 40mg Rosuvastatin in patients with ST elevation acute myocardial infarction (STEMI) after Percutaneous Coronary Intervention (PCI) over 2 months


  • Iram Aslam May Hospital / King Edward Medical University, Lahore
  • Bilal S. Mohydin Fatima Jinnah Medical University, Lahore
  • Waseem Ahmed Mayo Hospital / King Edward Medical University, Lahore



lipid profile, Percutaneous Coronary Intervention, Rosuvastatin, ST segment elevation myocardial infarction, Myocardial Infarction



Background: Diminished or total stoppage of blood circulation to a part of the myocardium leads to myocardial infarction (MI), frequently called "heart attack." MI is by and large associated with coronary artery disease. Atherosclerosis is the predominant cause of CAD. Atherosclerosis is a result of dyslipidemia. Statin is a lipid-lowering medication that also has anti-inflammatory properties, lowers oxidative stress, inhibits thrombogenic responses, stabilizes plaque, and improves endothelial function, resulting in enhanced myocardial perfusion. This research was designed because medical evidence on the advantages of 20mg rosuvastatin versus 40mg rosuvastatin for lowering peri-procedural myocardial injury and post PCI MACE in patients suffering from STEMI is limited in the Pakistani population.

Objective: The goal of this research work was to compare the clinical outcomes of using 20mg and 40mg rosuvastatin following percutaneous coronary intervention (PCI) in individuals suffering from STEMI over 2 months.

Material & Method: For six months, a RCT was conducted in the Cardiology department of Mayo Hospital, Lahore. Sixty-six patients were included after fulfilling the inclusion and exclusion criteria. Individuals enrolled in this trial were randomized to 2 groups: group A, in which patients were given 20 mg Rosuvastatin and group B, in which patients were given 40mg Rosuvastatin. All patients received PCI by experienced interventional cardiologists. Clopidogrel was prescribed for a year after the intervention, and aspirin was prescribed for lifelong. After 24 hours, 1 week, 6 weeks, and 2 months, patients in both groups were re-evaluated clinically.

Results: The patient’s mean age was 48.42±9.127 years, with 51 (77.27%) of them being male and 25 (37.86%) of them being diabetic. In terms of quantitative TnI, CKMB, ALT, HDL, LDL, TG, TC, and HbA1c, there was no significant difference among the two groups. Tolerability for both 20mg and 40 mg rosuvastatin was 100 percent at the end of the second month. In both groups, no MACE was found.

Conclusion: This research concluded that 40 mg rosuvastatin is just as safe and well tolerated as 20 mg rosuvastatin. After two months of PCI in individuals suffering from STEMI, both intensities are equally effective in terms of clinical outcome.


Author Biographies

Iram Aslam, May Hospital / King Edward Medical University, Lahore


Bilal S. Mohydin, Fatima Jinnah Medical University, Lahore

Professor of Cardiology

Waseem Ahmed, Mayo Hospital / King Edward Medical University, Lahore

Associate Professor of Cardiology



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