Hyperuricemia in acute coronary syndrome and its relation with metabolic syndrome
Keywords:Acute coronary syndrome, hyperuricemia, metabolic syndrome
INTRODUCTION: High mortality and morbidity are associated with coronary artery disease (CAD), the most common form of cardiovascular disease. In humans, uric acid is produced as a byproduct of purine decomposition. Numerous epidemiological studies have shown that high levels of blood uric acid are associated with an increased risk of ischemic heart disease and other cardiovascular disorders.
AIMS & OBJECTIVES: The objectives of the present study are: To determine frequency of hyperuricemia in acute coronary syndrome. To compare frequency of metabolic syndrome in patients of acute coronary syndrome with and without hyperuricemia.
MATERIAL & METHODS: It was a cross sectional study. Patients admitted with Acute Coronary Syndrome to the Punjab Institute of Cardiology Lahore between March 20 and September 20 of 2016 were included in this study. A total of 200 patients with Acute Coronary Syndrome who fulfilled the study's inclusion criteria and provided written informed consent were included. The demographic and clinical characteristics of each patient were recorded in the appropriate sections of the proforma, as required by the operational definition.
RESULTS: In our study, out of 200 cases of ACS, 26.5% were between 30-50 years of age while 73.5% were between 51-70 years. Mean age was calculated 54.24+8.91 years. There were 47.5% male and 52.5 females. Frequency of hyperuricemia in ACS was calculated as 29.5% and frequency of MetS in patients with ACS with and without hyperuricemia was recorded as 38.98% vs 19.15% with p value 0.003 showing a significant difference.
CONCLUSION: After analyzing data, we came to the conclusion that the prevalence of hyperuricemia is much greater in patients presenting with acute coronary syndrome, whereas the prevalence of metabolic syndrome is markedly higher in hyperuricemic cases compared to those without hyperuricemia.
KEYWORDS: Acute coronary syndrome, hyperuricemia, metabolic syndrome
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